diff --git a/CMakeLists.txt b/CMakeLists.txt
index f1e12dff..918c3191 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -106,6 +106,11 @@ mark_as_advanced(TRACY_VERBOSE)
 set_option(TRACY_DEMANGLE "[advanced] Don't use default demangling function - You'll need to provide your own" OFF)
 mark_as_advanced(TRACY_DEMANGLE)
 
+# handle incompatible combinations
+if(TRACY_MANUAL_LIFETIME AND NOT TRACY_DELAYED_INIT)
+    message(FATAL_ERROR "TRACY_MANUAL_LIFETIME can not be activated with disabled TRACY_DELAYED_INIT")
+endif()
+
 if(NOT TRACY_STATIC)
     target_compile_definitions(TracyClient PRIVATE TRACY_EXPORTS)
     target_compile_definitions(TracyClient PUBLIC TRACY_IMPORTS)
diff --git a/public/client/TracyProfiler.cpp b/public/client/TracyProfiler.cpp
index a551aa42..75116fef 100644
--- a/public/client/TracyProfiler.cpp
+++ b/public/client/TracyProfiler.cpp
@@ -81,6 +81,10 @@
 #include "TracySysTrace.hpp"
 #include "../tracy/TracyC.h"
 
+#if defined TRACY_MANUAL_LIFETIME && !defined(TRACY_DELAYED_INIT)
+#  error "TRACY_MANUAL_LIFETIME requires enabled TRACY_DELAYED_INIT"
+#endif
+
 #ifdef TRACY_PORT
 #  ifndef TRACY_DATA_PORT
 #    define TRACY_DATA_PORT TRACY_PORT
@@ -4907,7 +4911,7 @@ TRACY_API void ___tracy_fiber_enter( const char* fiber ){ tracy::Profiler::Enter
 TRACY_API void ___tracy_fiber_leave( void ){ tracy::Profiler::LeaveFiber(); }
 #endif
 
-#  ifdef TRACY_MANUAL_LIFETIME
+#  if defined TRACY_MANUAL_LIFETIME && defined TRACY_DELAYED_INIT
 TRACY_API void ___tracy_startup_profiler( void )
 {
     tracy::StartupProfiler();